Reacción #47873

Ecuación de reacción

5,7-dichloro-3-isopropylpyrazolo[4,3-d]pyrimidine

1-(R,S)-(hydroxymethyl)propylamine

→

7-[1 (R,S)-(hydroxymethyl)propyl]amino-5-[1(R,S)-(hydroxymethyl)propyl]amino-3-isopropyl-pyrazolo[4,3-d]pyrimidine

Rendimiento 80.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was evaporated to dryness in vacuo
2. 2
   OtroThe product was purified by column chromatography on silica gel
3. 3
   workup.ADDITIONThe mixture of chloroform/methanol (96/4)

Procedimiento

The mixture of 5,7-dichloro-3-isopropylpyrazolo[4,3-d]pyrimidine (100 mg; 0.331 mmol) and 2 mL 1-(R,S)-(hydroxymethyl)propylamine was heated at 120° C. for 6 hours. The reaction mixture was evaporated to dryness in vacuo. The product was purified by column chromatography on silica gel. The mixture of chloroform/methanol (96/4) was used as a mobile phase. Yield=80%; white syrupy; MS (ES+): 337.4 (100%, M+H+). 1H-NMR (300 MHz, CDCl3): 0.90-1.03 m (6H), 1.26 d (6H), 1.50-1.71 m (4H), 2.48 bs (1H), 3.07 m (1H), 3.40 m (1H), 3.59-3.90 m (4H).

Fuente