Reacción #47844

Ecuación de reacción

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

cyclohexylamine

→

titled compound

Rendimiento 24.0%

1-cyclohexylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Rendimiento 24.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was removed under a reduced pressure
2. 2
   OtroThe resulting residue was purified by flash chromatography

Procedimiento

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and cyclohexylamine (132.86 mg, 0.15 mL, 1.34 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 25 mg of the titled compound (yield: 24%).

Fuente