Reacción #47826

Ecuación de reacción

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

Rendimiento 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Rendimiento 52.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   OtroThe organic layer was separated
3. 3
   Concentraciónconcentrated under a reduced pressure
4. 4
   OtroThe resulting residue was purified by flash chromatography

Procedimiento

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

Fuente