Reacción #47817

Ecuación de reacción

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester

p-toluenesulfonic acid

→

titled compound

Rendimiento 62.1%

1-oxo-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Methyl Ester

Rendimiento 62.1%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 24 hrs
2. 2
   LavadoThe resulting mixture washed with sodium bicarbonate
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   OtroThe organic layer was separated
5. 5
   Secadodried over anhydrous MgSO4
6. 6
   Concentraciónconcentrated under a reduced pressure
7. 7
   OtroThen, the resulting residue was purified by flash chromatography

Procedimiento

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester (2 g, 4.85 mmol) obtained in Example 7 was dissolved in methanol, p-toluenesulfonic acid (92 mg, 0.49 mmol) was added thereto, and refluxed for 24 hrs. The resulting mixture washed with sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 1.2 g of the titled compound (yield: 62%).

Fuente