Reacción #47790

Ecuación de reacción

2-amino-4-chloro-6-methylpyrimidine

3-amino-N-(4-amino-2-methyl-quinolin-6-yl)-propionamide

diisopropyl ethylamine

→

title compound

Rendimiento 36.6%

3-(2-Amino-6-methyl-pyrimidin-4-ylamino)-N-(4-amino-2-methyl-quinolin-6-yl)-propionamide

Rendimiento 36.6%

Disolventes

dimethylacetamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter evaporation of the solvent the residue
2. 2
   Otrowas purified by HPLC

Procedimiento

A solution of 0.05 g (0.35 mmol) 2-amino-4-chloro-6-methylpyrimidine, 0.204 mg (0.35 mmol) 3-amino-N-(4-amino-2-methyl-quinolin-6-yl)-propionamide and 0.18 mg (1.39 mmol) diisopropyl ethylamine in 5 ml dimethylacetamide was stirred at 100° C. for 2 h. After evaporation of the solvent the residue was purified by HPLC and lyophilized to yield 45 mg of the title compound. MS 352.3 (M+H)+, 1H-NMR (DMSO-d6) δ 2.20 (s, 3H), 2.55 (s, 3H), 2.70 (m, 2H), 3.65 (m, 2H), 6.1 (s, NH), 7.70-7.90 (m, 5H), 8.60-8.80 (br.s., NH), 13.85 (br.s., NH).

Fuente