Reacción #477183

Ecuación de reacción

2,3-Dioxo-1-p-tolylpiperidine-4-carbonitrile

hydrazine hydrochloride

acetic acid

→

compound

Rendimiento 86.0%

3-amino-5,6-dihydro-6-p-tolyl-1H-pyrazolo[3,4-c]pyridin-7(4H)-one

Rendimiento 86.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONdissolved
2. 2
   workup.ADDITIONAfter adding
3. 3
   OtroAfter removing ethanol
4. 4
   workup.DISTILLATIONby distillation
5. 5
   Filtraciónthe produced solid was filtered
6. 6
   Otroacetic acid was completely removed
7. 7
   Lavadoby washing with NaHCO3 twice

Procedimiento

2,3-Dioxo-1-p-tolylpiperidine-4-carbonitrile (3.56 g, 15.597 mmol) was added to anhydrous ethanol (52.0 mL) and dissolved by heating to 60° C. After adding hydrazine hydrochloride (1.06 mL, 21.836 mmol) and glacial acetic acid (1.34 mL, 23.396 mmol) room temperature, reaction was carried out for 2 days. After removing ethanol by distillation, the produced solid was filtered and then acetic acid was completely removed by washing with NaHCO3 twice or more times. A target compound (3.25 g, 13.414 mmol, 86.0%) was yielded as white solid.

Fuente