Reacción #477182

Ecuación de reacción

4-(p-Tolylamino)butanenitrile

diethyl oxalate

sodium ethoxide

→

compound

Rendimiento 51.6%

2,3-dioxo-1-p-tolylpiperidine-4-carbonitrile

Rendimiento 51.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 2 days
2. 2
   Filtraciónthe concentrated solution was filtered

Procedimiento

4-(p-Tolylamino)butanenitrile (13.23 g, 75.929 mmol) was dissolved in ethanol (189.8 mL). After adding diethyl oxalate (10.3 mL, 75.929 mmol) and then adding sodium ethoxide (34.0 mL, 91.115 mmol) to the resultant reaction mixture, reaction was carried out under reflux for 2 days. The reaction solution was cooled to room temperature and the concentrated solution was filtered. A target compound (8.94 g, 39.167 mmol, 51.6%) was yielded as yellow solid.

Fuente