Reacción #4744

Ecuación de reacción

ammonia

3-hydroxybenzaldehyde

3-methylpiperidine

formic acid

→

3-[(3-Methylpiperidin-1-yl)methyl]phenol

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawith cooling
2. 2
   TemperaturaWhen the reaction mixture has cooled to room temperature
3. 3
   Filtraciónthe precipitated solid is filtered off
4. 4
   Otrorecrystallised from ethanol

Procedimiento

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

Fuente