Reacción #473563

Ecuación de reacción

1H-pyrazole

iodonaphthalene

Cs2CO3

→

1-(naphthalen-1-yl)-1H-pyrazole

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas evacuated
2. 2
   workup.ADDITIONfilled with nitrogen twice
3. 3
   workup.WAITat 120° C. for 2 days
4. 4
   TemperaturaThe reaction mixture was then cooled to room temperature
5. 5
   workup.ADDITIONdiluted with ethyl acetate
6. 6
   Filtraciónfiltered through silica gel
7. 7
   Concentraciónconcentrated

Procedimiento

A mixture of 1H-pyrazole (300 mg, 4.4 mmol), iodonaphthalene (1.1 g, 4.4 mmol), copper (I) iodide (126 mg, 0.66 mmol), Cs2CO3 (2.15 g, 6.6 mmol) in DMF (5 mL) was evacuated and filled with nitrogen twice. The reaction was then stirred at room temperature for 30 minutes and then at 120° C. for 2 days. The reaction mixture was then cooled to room temperature, diluted with ethyl acetate, filtered through silica gel and concentrated to give 1-(naphthalen-1-yl)-1H-pyrazole as pure solid. (800 mg, 93%).

Fuente