Reacción #4724

Ecuación de reacción

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture is briefly heated to boiling
2. 2
   FiltraciónThe sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   Concentraciónthe filtrate is concentrated by evaporation
4. 4
   Otropurified by preparative layer chromatography

Procedimiento

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

Fuente