Reacción #472254

Ecuación de reacción

lithium hydroxide monohydrate

Methyl 3-cyano-5-iodo-4-methoxybenzoate

→

title compound

Rendimiento 95.0%

3-cyano-5-iodo-4-methoxybenzoic acid

Rendimiento 95.0%

Disolventes

water

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISTILLATIONThe organic solvent was distilled off under reduced pressure
2. 2
   Lavadothe aqueous layer was washed with n-hexane
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic layer was washed with saturated brine
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedimiento

Methyl 3-cyano-5-iodo-4-methoxybenzoate (8.00 g) was dissolved in tetrahydrofuran (100 mL) and water (50 mL), and lithium hydroxide monohydrate (423 g) was added to the solution, and then the mixture was stirred at room temperature for 4 hours. The organic solvent was distilled off under reduced pressure and the aqueous layer was washed with n-hexane. The aqueous layer was acidified with 2N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (7.26 g) as a colorless crystal.

Fuente