Reacción #472252

Ecuación de reacción

N-iodosuccinimide

trifluoromethanesulfonic acid

Methyl 3-cyano-4-hydroxybenzoate

→

title compound

Rendimiento 102.0%

methyl 3-cyano-4-hydroxy-5-iodobenzoate

Rendimiento 102.0%

Disolventes

methanol

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
2. 2
   Lavadothe obtained residue was washed with water

Procedimiento

Methyl 3-cyano-4-hydroxybenzoate (6.47 g) was dissolved in chloroform (80 mL) and methanol (10 mL), and N-iodosuccinimide (8.63 g) and trifluoromethanesulfonic acid (2.5 mL) were added to the solution, and then the mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure and the obtained residue was washed with water to obtain the title compound (11.29 g) as a pale yellow crystal.

Fuente