Reacción #4722

Ecuación de reacción

triethylamine

phenyl isocyanide dichloride

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide

→

N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónSolid triethylammonium chloride is filtered off
2. 2
   Concentraciónthe filtrate is concentrated by evaporation under vacuum
3. 3
   Otrothe solid residue is recrystallised from ethanol

Procedimiento

1.4 ml (10 mmol) of triethylamine and 0.7 ml (5 mmol) of phenyl isocyanide dichloride are added to 1.5 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide in 30 ml of THF and the mixture is stirred at room temperature until the reaction is quantitative. Solid triethylammonium chloride is filtered off, the filtrate is concentrated by evaporation under vacuum, and the solid residue is recrystallised from ethanol. The analytical values are summarized in Table II.

Fuente