Reacción #4712

Ecuación de reacción

methylisothiocyanate

N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide

→

2-(Methylaminothioxomethyl)-N-[3-[3-(1-piperidinylmethyl)phenoxy]-propyl]-hydrazine carboxamide

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe precipitate obtained
2. 2
   Filtraciónis filtered off
3. 3
   Otrorecrystallised from ethanol

Procedimiento

0.5 g (6.6 mmol) of methylisothiocyanate are added to 1.0 g (3.3 mmol) of N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide in 20 ml of THF and the mixture is stirred at room temperature for 12 hours. The precipitate obtained is filtered off and recrystallised from ethanol. The analytical values are summarized in Table I.

Fuente