Reacción #47078

Ecuación de reacción

chloroacetonitrile

3-fluorophenol

potassium carbonate

→

product 386

Rendimiento 94.2%

3-Fluorophenoxyacetonitrile

Rendimiento 94.2%

Disolventes

EtOAc

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is cooled to RT
2. 2
   Lavadowashed with water, brine
3. 3
   Secadodried (MgSO4)
4. 4
   Filtraciónfiltered
5. 5
   OtroThe filtrate is evaporated
6. 6
   Otrothe residue purified by chromatography on silica gel
7. 7
   Lavadoelution with dichloromethane

Procedimiento

To a solution of 3-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 712 mg of the product 386.

Fuente