Reacción #4705

Ecuación de reacción

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methylisocyanate

Ether

→

N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Otrothe precipitation
3. 3
   Filtraciónfiltered
4. 4
   Lavadowashed with ether
5. 5
   Otrorecrystallised from ethanol

Procedimiento

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Fuente