Reacción #47043

Ecuación de reacción

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

1-chloromethylnaphthalene

→

product 213

Rendimiento 19.8%

2-[(Naphthalen-1-yl)methylthio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Rendimiento 19.8%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated to dryness
2. 2
   FiltraciónThe insoluble material is filtered

Procedimiento

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 1-chloromethylnaphthalene (0.277 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 67 mg of the product 213. 1H NMR (DMSO-d6) δ 11.20 (s, 2 H), 8.40-8.25 (m, 1 H), 8.10-7.90 (m, 2 H), 7.90-7.80 (m, 1 H), 7.80-7.50 (3, H), 7.20-6.70 (m, 10 H), 5.79 (s, 2 H), 4.85 (s, 2 H); MS: m/z 395 (M++1).

Fuente