Reacción #470396

Ecuación de reacción

N-(2-nitrophenyl)biphenyl-2-amine

hydrogen

→

N1-(biphenyl-2-yl)benzene-1,2-diamine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solution was filtered through Celite
2. 2
   Otroto remove the catalyst, Celite
3. 3
   Lavadowas washed with dichloromethane
4. 4
   Otrothe filtrate was evaporated
5. 5
   Otroto yield a brown oil, 14.8 g (84%)
6. 6
   OtroThe product was used for the next step without further purification

Procedimiento

N-(2-nitrophenyl)biphenyl-2-amine (19.69 g, 67.8 mmol), 10% palladium on carbon (0.29 g, 0.27 mmol), and 150 mL of ethanol was added to a Parr hydrogenator bottle. The mixture was hydrogenated on a Parr hydrogenator until no more hydrogen was taken up by the solution. The solution was filtered through Celite to remove the catalyst, Celite was washed with dichloromethane, the filtrate was evaporated to yield a brown oil, 14.8 g (84%). The product was used for the next step without further purification.

Fuente