Reacción #470392

Ecuación de reacción

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

Rendimiento 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

Rendimiento 47.9%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooled to room temperature
2. 2
   ExtracciónThe mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   OtroThe solvent was evaporated
4. 4
   Otrothe residue was purified by column chromatography

Procedimiento

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

Fuente