Reacción #470391

Ecuación de reacción

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated up
2. 2
   Temperaturato reflux for 24 hours
3. 3
   Filtraciónthe precipitate was collected by filtration
4. 4
   OtroThe product was purified by column chromatography

Procedimiento

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

Fuente