Reacción #470387

Ecuación de reacción

N1-phenylbenzene-1,2-diamine

benzaldehyde

→

desired product

Rendimiento 37.0%

1,2-diphenyl-1H-benzo[d]imidazole

Rendimiento 37.0%

Disolventes

methoxylethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated up
2. 2
   Temperaturato reflux for 48 hours
3. 3
   Otrothe solvent was evaporated
4. 4
   OtroThe residue was purified by column chromatography

Procedimiento

N1-phenylbenzene-1,2-diamine (4.15 g, 22 mmol) and benzaldehyde (2.1 g, 20 mmol) were mixed with methoxylethanol (60 ml) in a three-neck flask. The mixture was heated up to reflux for 48 hours. After cooled to room temperature, the solvent was evaporated. The residue was purified by column chromatography using dichloromethane to 5% of ethyl acetate in dichloromethane as eluent. 2 g of desired product was obtained.

Fuente