Reacción #470378

Ecuación de reacción

Methylchloroformate

maleimide

NMM

→

product

Rendimiento 55.0%

N-(Methoxycarbonyl)maleimide

Rendimiento 55.0%

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   Lavadowashed with EtOAc
3. 3
   Lavadowashed with cold water
4. 4
   Secadodried over anhydrous Na2SO4
5. 5
   FiltraciónAfter filtration and evaporation under vacuum a pink solid
6. 6
   Otrowas obtained
7. 7
   OtroPurification by column chromatography on silica gel (Hexane-EtOAc, 1:1

Procedimiento

Methylchloroformate (4.4 mL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 mL of EtOAc at 0° C. The suspension was stirred at 0° C. for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

Fuente