Reacción #470377

Ecuación de reacción

cyclen

2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester

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product

Rendimiento 81.3%

5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-(1,4,7,10-tetraazacyclododec-1-yl)pentanoic acid benzyl ester

Rendimiento 81.3%

Disolventes

CH3CN

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added dropwise
2. 2
   FiltraciónThe precipitate is filtered off
3. 3
   Lavadowashed thoroughly with acetonitrile

Procedimiento

55 g of cyclen base (320 mmol) are dissolved in 550 ml of CH3CN, to which 119.8 g of brominated derivative (2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester, 288 mmol) dissolved in 550 ml of CH3CN are added dropwise. The medium is stirred at ambient temperature overnight. The precipitate is filtered off and washed thoroughly with acetonitrile. 138 g of product are obtained in the form of a white powder (corrected yield 81.3%).

Fuente