Reacción #47034

Ecuación de reacción

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

3,4-dichlorobenzyl chloride

→

product 204

Rendimiento 61.5%

2-[(3,4-Dichlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Rendimiento 61.5%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated to dryness
2. 2
   FiltraciónThe insoluble material is filtered

Procedimiento

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 3,4-dichlorobenzyl chloride (0.218 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 217 mg of the product 204. 1H NMR (DMSO-d6) δ 11.40 (s, 2 H), 7.95 (d, 1 H), 7.78 (d, 1 H), 7.65 (d, 1 H), 7.20-6.90 (m, 6 H), 6.90-6.60 (m, 4 H), 5.78 (s, 2 H), 4.85 (s, 2 H); MS: m/z 413 (M++1).

Fuente