Reacción #4701

Ecuación de reacción

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Otrothe precipitate formed
3. 3
   Filtraciónfiltered
4. 4
   Lavadowashed with ether
5. 5
   Otrorecrystallised from ethanol

Procedimiento

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Fuente