Reacción #469442

Ecuación de reacción

1-(4-Bromophenyl)-3-(2-thienyl)-2-propen-1-one

hydrazine hydrate

→

3-(4-bromophenyl)-5-(2-thienyl)-pyrazoline

Rendimiento 98.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturaunder reflux for 3 hours
3. 3
   workup.DISTILLATIONthe solvent was distilled off

Procedimiento

1-(4-Bromophenyl)-3-(2-thienyl)-2-propen-1-one (3.0 g, 10.2 mmol) and hydrazine hydrate (1.0 g, 20 mmol) were added to ethanol (30 ml) and heated under reflux for 3 hours. After the mixture was allowed to cool to room temperature, the solvent was distilled off to obtain 3.0 g (98%) of the desired 3-(4-bromophenyl)-5-(2-thienyl)-pyrazoline in the form of a resinous material.

Fuente