Reacción #46944

Ecuación de reacción

(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

potassium phthalimide

Dimethyl formamide

→

(S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Rendimiento 61.7%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais heated for 5 hours
2. 2
   Temperaturaat reflux temperature
3. 3
   Filtraciónfiltered the solid

Procedimiento

The mixture of (5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone (60 g), potassium phthalimide (40 g) and Dimethyl formamide (400 ml) is heated for 5 hours at reflux temperature. The reaction mixture is cooled to ambient temperature, poured in to 2 L water and filtered the solid to give 50 gm (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide.

Fuente