Reacción #46929

ord-babaad3c2e6448d8a81dcfd8f4619454

Ecuación de reacción

O=Cc1ccccc1F
2-Fluorobenzaldehyde
C=CC(C)=O
but-3-en-2-one
Nc1ccc(S(N)(=O)=O)cc1
p-aminosulfonyl phenylamine
→
Cc1ccc(-c2ccccc2F)n1-c1ccc(S(N)(=O)=O)cc1
titled compound
Cc1ccc(-c2ccccc2F)n1-c1ccc(S(N)(=O)=O)cc1
4-[2-(2-fluoro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonamide

Reactantes

O=Cc1ccccc1F
2-Fluorobenzaldehyde
C=CC(C)=O
but-3-en-2-one
Nc1ccc(S(N)(=O)=O)cc1
p-aminosulfonyl phenylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

2-Fluorobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-aminosulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 2.18 (3H), 4.71 (2H), 6.13 (1H), 6.34 (1H), 7.05-7.90 (8H); MS (ESI) m/z 331 (M+H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07741364B2uspto-grants-2010_06