Reacción #4691

Ecuación de reacción

hydrogen chloride

product

3-ethyl-5-(4-methoxy-phenyl)-4-phenyl-4H-1,2,4-triazole

isopropyl ether

→

3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture was filtered
2. 2
   Filtraciónfiltered
3. 3
   Otrowas dried
4. 4
   workup.DISSOLUTIONThe product was dissolved in 350 ml of tetrahydrofuran
5. 5
   Filtraciónthe solution was filtered
6. 6
   Concentraciónconcentrated to a volume of 75 ml
7. 7
   TemperaturaThe mixture was cooled
8. 8
   Filtracióniced and filtered
9. 9
   Lavadothe recovered product was washed with tetrahydrofuran
10. 10
    Otrodried

Procedimiento

2.85 ml of a 6.4N hydrogen chloride solution in ethanol were added to a solution of 5.1 g of the product of Example 6 in 5.1 ml of ethanol and then isopropyl ether was added thereto. The mixture was filtered and the recovered product was empasted several times with isopropyl ether, filtered and was dried. The product was dissolved in 350 ml of tetrahydrofuran and the solution was filtered and concentrated to a volume of 75 ml. The mixture was cooled, iced and filtered and the recovered product was washed with tetrahydrofuran and dried to obtain 3.3 g of 3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride melting towards 150° C. with decomposition.

Fuente