Reacción #46905

Ecuación de reacción

4-Carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate

4-carbamoylphenyl 2-[2-(2,6-dichlorophenylamino)-phenyl]acetate

Lawesson reagent

→

compound 6

Rendimiento 91.0%

[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 4-thiocarbamoyl-phenyl ester

Rendimiento 91.0%

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed under reduced pressure
2. 2
   Otrothe crude residue was purified by silica gel column (dichloromethane/methyl alcohol 9.5/0.5)

Procedimiento

4-Carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate (5, 480 mg, 1.14 mmol) and Lawesson reagent (460 mg, 1.14 mmol) were dissolved in 20 ml of anhydrous benzene. The reaction was warmed to 50° C. and stirred for 6 h. The solvent was removed under reduced pressure; the crude residue was purified by silica gel column (dichloromethane/methyl alcohol 9.5/0.5) to furnish the pure compound 6 (446 mg, 91% yield).

Fuente