Reacción #4687

Ecuación de reacción

4-Cyano-2(R,S)-α-naphthoxybutyric acid

KOH

α-naphthoxymalonic acid diethyl ester

acrylonitrile

→

(2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine
2. 2
   Secadodried over sodium sulphate
3. 3
   Concentraciónconcentrated by evaporation

Procedimiento

4-Cyano-2(R,S)-α-naphthoxybutyric acid: 0.11 ml of a 50% aqueous KOH solution is added at 0°, while stirring, to a mixture of 5.0 g of α-naphthoxymalonic acid diethyl ester and 1.09 ml of acrylonitrile. The reaction mixture is stirred for 5 days at room temperature and then dissolved in ethyl acetate. The ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine, dried over sodium sulphate and concentrated by evaporation, leaving (2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester.

Fuente