Reacción #46773

Ecuación de reacción

HCl

(5-fluoro-2-methyl-indol-1-yl)-acetic acid

biphenyl-4-thiol

iodine

→

title compound

[3-(Biphenyl-4-ylsulfanyl)-5-fluoro-2-methyl-indol-1-yl]-acetic acid

Disolventes

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe organics extracted with EtOAc
2. 2
   ExtracciónThe EtOAc extractions
3. 3
   Lavadowashed with brine
4. 4
   Secadodried (MgSO4)
5. 5
   Otroevaporated under reduced pressure
6. 6
   Otroto give crude material
7. 7
   OtroPurification

Procedimiento

To a solution of (5-fluoro-2-methyl-indol-1-yl)-acetic acid (0.5 g) and biphenyl-4-thiol (0.19 g) in DMF (5 ml) was added iodine (0.25 g). After stirring at RT overnight the mixture was poured into water, the pH adjusted to 3 using 1M HCl and the organics extracted with EtOAc. The EtOAc extractions were combined, washed with brine, dried (MgSO4) and evaporated under reduced pressure to give crude material. Purification using RPHPLC gave the title compound as a pink solid (0.1 μg).

Fuente