Reacción #46768

Ecuación de reacción

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

Rendimiento 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

Rendimiento 98.3%

Disolventes

CH2Cl2

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 100 mL round bottom flask equipped with a stir bar
2. 2
   Lavadowashed with water (3×100 mL)
3. 3
   SecadoOrganic layer was dried over anhydrous sodium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

Fuente