Reacción #46758

Ecuación de reacción

K2CO3

4-methoxy-2-fluoro-1-nitrobenzene

Mono-N-Boc-1,2-diaminoethane

→

desired product

Rendimiento 104.0%

[2-(5-Methoxy-2-nitrophenylamino)-ethyl]-carbamic acid tert-butyl ester

Rendimiento 104.0%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 2 L flask equipped with a stir bar
2. 2
   OtroThe reaction mixture was triturated with ice cold water (1.2 L)
3. 3
   Filtraciónthe resulting yellow precipitate was collected by vacuum filtration
4. 4
   LavadoThe precipitate washed several times with water (5×1 L)
5. 5
   Otrodried on a high vacuum for 48 h

Procedimiento

A 2 L flask equipped with a stir bar was charged with DMSO (800 mL), K2CO3 (161 g, 1.6 mol) and 4-methoxy-2-fluoro-1-nitrobenzene (10 g, 0.58 mol). Mono-N-Boc-1,2-diaminoethane (94 g, 0.55 mol) was added to the reaction mixture and stirred for 12 h at 60° C. The reaction mixture was triturated with ice cold water (1.2 L) and the resulting yellow precipitate was collected by vacuum filtration. The precipitate washed several times with water (5×1 L) and dried on a high vacuum for 48 h to give the desired product as a bright yellow solid (178 g, 98%.)

Fuente