Reacción #46665

Ecuación de reacción

hydrochloric acid

diethyl 2-methyl-2-(4-pyridylmethyl)malonate

→

2-methyl-3-(4-pyridyl)propionic acid

Rendimiento 100.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was refluxed overnight
2. 2
   Lavadowashed with hexane (100 ml)
3. 3
   Otroto remove sodium hydride oil
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   FiltraciónThe resulting crystals were filtered off with ethyl acetate

Procedimiento

Next, 6 N hydrochloric acid (96.8 ml, 581 mmol) was added to diethyl 2-methyl-2-(4-pyridylmethyl)malonate (17.2 g, 64.6 mmol), and the mixture was refluxed overnight. The reaction mixture was allowed to stand, then washed with hexane (100 ml) to remove sodium hydride oil contained in diethyl 2-methyl-2-(4-pyridylmethyl)malonate and concentrated under reduced pressure. The resulting crystals were filtered off with ethyl acetate to give 2-methyl-3-(4-pyridyl)propionic acid (10.7 g, 82%) as pale pink crystals.

Fuente