Reacción #466184

ord-259923fed0f244e6852dbf2247aaf447

Ecuación de reacción

C1CCOC1.C1CCOC1
THF tetrahydrofuran
CC(C)[N-]C(C)C.CC(C)[N-]C(C)C.[Li+].[Li+]
LDA lithium diisopropylamide
[Li][CH2]CCC.[Li][CH2]CCC
BuLi butyllithium
COCCOC.COCCOC
DME dimethoxyethane
→
CN(C)C=O.CN(C)C=O
DMF dimethylformamide

Reactantes

C1CCOC1.C1CCOC1
THF tetrahydrofuran
CC(C)[N-]C(C)C.CC(C)[N-]C(C)C.[Li+].[Li+]
LDA lithium diisopropylamide
[Li][CH2]CCC.[Li][CH2]CCC
BuLi butyllithium
COCCOC.COCCOC
DME dimethoxyethane

Reactivos

Ninguno

Disolventes

ClCCl.ClCCl
CH2Cl2 dichloro-methane
CCOCC.CCOCC
Et2O diethylether
CCOC(C)=O.CCOC(C)=O
EtOAc ethyl acetate

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroRT—room temperature

Procedimiento

THF—tetrahydrofuran; DME—dimethoxyethane; EtOAc—ethyl acetate; Et2O—diethylether; RT—room temperature; LDA—lithium diisopropylamide; CH2Cl2—dichloro-methane; tic—thin layer chromatography; BuLi—butyllithium

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06297264B1uspto-grants-2001_10