Reacción #465961

Ecuación de reacción

3,4,5,6-tetrafluoro-2-cyanopyridine

ammonium hydroxide

→

4-amino-3,5,6-trifluoro-2-cyanopyridine

Rendimiento 92.0%

Disolventes

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solid was collected
2. 2
   Otroair dried

Procedimiento

To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.

Fuente