Reacción #46585

Ecuación de reacción

2-Methoxyethylamine

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

DIEA

→

title compound

Rendimiento 90.0%

2-Amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine

Rendimiento 90.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthen was concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   Extracciónthe solution was extracted with ethyl acetate
4. 4
   LavadoThe combined organic extracts were washed with brine
5. 5
   Secadodried over Na2SO4
6. 6
   Concentraciónconcentrated

Procedimiento

2-Methoxyethylamine (1.49 mL, 17.16 mmole) was added to a solution of 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide (1.49 g, 4.29 mmole) and DIEA (2.24 mL, 12.87 mmole) in CH2Cl2 (10 mL) at RT. The reaction was stirred overnight then was concentrated in vacuo. The residue was diluted with water and the solution was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated to afford the title compound (1.00 g, 90%) as a light brown liquid after drying in vacuo: MS (ES) m/e 260/262 (M+H)+.

Fuente