Reacción #464697

ord-79cb315a8dbc4f05b9b25a9ec4d056ca

Ecuación de reacción

CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
CNCCOCc1ccccc1
N-(2-(phenylmethoxy)ethyl)methylamine
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
→
CCc1ncc2c(=O)[nH]c3c(N(C)CCOCc4ccccc4)ncnc3n12
9-Ethyl-4-[(2-(phenylmethoxy)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

Reactantes

CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
CNCCOCc1ccccc1
N-(2-(phenylmethoxy)ethyl)methylamine
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared by treatment of N-(2-(phenylmethoxy)ethyl)methylamine with 4,6-dichloro-5-nitropyrimidine, followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride and cyclization with carbonyldiimidazole.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06025489uspto-grants-2000_02