Reacción #464692

ord-3212f7b590b4430483b6c6024c3e6bfd

Ecuación de reacción

CCc1ncc[nH]1
2-ethylimidazole
C1=CCCCC1
cyclohexene
O=C(n1ccnc1)n1ccnc1
carbonyidiimidazole
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNC1CCN(C)CC1
1-methyl-4-(methylamino)piperidine
→
CCc1ncc2c(=O)[nH]c3c(NCC4CCN(C)CC4)ncnc3n12
9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1 -h]pteridin-6(5H)-one

Reactantes

CCc1ncc[nH]1
2-ethylimidazole
C1=CCCCC1
cyclohexene
O=C(n1ccnc1)n1ccnc1
carbonyidiimidazole
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNC1CCN(C)CC1
1-methyl-4-(methylamino)piperidine

Reactivos

[Pd]
palladium on carbon

Disolventes

CCO
ethanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 1-methyl-4-(methylamino)piperidine followed by reaction with 2-ethylimidazole, reduction with palladium on carbon and cyclohexene in refluxing ethanol, and cyclization with carbonyidiimidazole.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06025489uspto-grants-2000_02