Reacción #46458

Ecuación de reacción

2-Bromo-4-methyl-6-iodophenol

cinnamyl bromide

Diisopropylethylamine

→

1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene

Rendimiento 101.2%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe DMF was removed under vacuum, and 1M HCl
2. 2
   workup.ADDITIONwas added until the residue
3. 3
   ExtracciónThe mixture was extracted with ethyl acetate
4. 4
   Secadothe combined organic phase was dried over magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

2-Bromo-4-methyl-6-iodophenol (7.82 gm, 25 mmol) and cinnamyl bromide (4.93 g, 25 mmol) were added to DMF (20 ml). Diisopropylethylamine (5.3 ml, 30.4 mmol) was added and the mixture heated to 60° C. for 15 minutes and then allowed stir for 16 hours at room temperature. The DMF was removed under vacuum, and 1M HCl was added until the residue was acidic. The mixture was extracted with ethyl acetate, and the combined organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 100% yield).

Fuente