Reacción #46395

Ecuación de reacción

ethyl 4-pyrazole carboxylate

potassium carbonate

1-bromo-3-phenylpropane

→

ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe suspension was refluxed overnight
2. 2
   Otroafter which the solvent was removed under reduced pressure
3. 3
   OtroThe residue was partitioned between ethyl acetate and water
4. 4
   Secadothe organic layer dried over magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Otrothe filtrate evaporated under reduced pressure
7. 7
   Otroto give an oil, which
8. 8
   Otrowas purified by preparative TLC

Procedimiento

To a solution of ethyl 4-pyrazole carboxylate (3.57 mmol) in acetone (30 ml) was added potassium carbonate (35.7 mmol) and 1-bromo-3-phenylpropane (3.57 mmol). The suspension was refluxed overnight, after which the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water, the organic layer dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give an oil, which was purified by preparative TLC, to give ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate.

Fuente