Reacción #46383

Ecuación de reacción

(S)-2-Aminomethylpyrrolidine-1-carboxylic acid tert-butyl ester

6-chloronicotinonitrile

potassium carbonate

diisopropylethylamine

→

title compound

Rendimiento 44.2%

(S)-2-[(5-Cyano-pyridin-2-ylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Rendimiento 44.2%

Disolventes

xylene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   Filtraciónthe mixture filtered through kieselguhr
3. 3
   OtroThe filtrate was evaporated
4. 4
   Otrothe residue chromatographed on silica gel
5. 5
   Lavadoeluting with ethyl acetate-hexane mixtures

Procedimiento

(S)-2-Aminomethylpyrrolidine-1-carboxylic acid tert-butyl ester (0.3 g), 6-chloronicotinonitrile (0.21 g), potassium carbonate (0.41 g) and diisopropylethylamine (0.78 ml) were heated in xylene at 130° C. for 26 h, cooled and the mixture filtered through kieselguhr. The filtrate was evaporated and the residue chromatographed on silica gel, eluting with ethyl acetate-hexane mixtures to afford the title compound (0.2 g). Mass Spectrum (API+): Found 303 (MH+). C16H22N4O2 requires 302.

Fuente