Reacción #46375

Ecuación de reacción

(S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester

2-chloro-5-cyanopyridine

diisopropylethylamine

→

title compound

Rendimiento 52.3%

2-[(5-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester

Rendimiento 52.3%

Condiciones de reacción

Procedimiento

The title compound (1.54 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (2.0 g) and 2-chloro-5-cyanopyridine (1.29 g) in the presence of diisopropylethylamine (1.21 g) according to the method of D28.

Fuente