Reacción #463287

Ecuación de reacción

chloroformic acid benzyl ester

6-aminohexan-1-ol

sodium hydrogen carbonate

→

6-(N-benzyloxycarbonylamino)hexan-1-ol

Disolventes

acetone

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated to approximately 70 ml
2. 2
   Filtraciónthe white precipitate is filtered off
3. 3
   Lavadowashed with approximately 20 ml of water
4. 4
   Secadodried over magnesium sulfate
5. 5
   Filtraciónthe magnesium sulfate is filtered off
6. 6
   Concentraciónthe residue is concentrated to dryness by evaporation

Procedimiento

7.06 ml (47 mmol) of chloroformic acid benzyl ester are added dropwise to a solution of 5.52 g (47 mmol) of 6-aminohexan-1-ol and 3.95 g (47 mmol) of sodium hydrogen carbonate in 100 ml of acetone and 50 ml of water. The mixture is stirred at room temperature for 18 hours and concentrated to approximately 70 ml, and the white precipitate is filtered off, washed with approximately 20 ml of water, taken up in 250 ml of methylene chloride and dried over magnesium sulfate; the magnesium sulfate is filtered off and the residue is concentrated to dryness by evaporation. 6-(N-benzyloxycarbonylamino)hexan-1-ol is obtained in the form of white crystals having a melting point of 58°-60°.

Fuente