Reacción #46295

Ecuación de reacción

4-hydroxybutylamine

tert-butyl bromoacetate

→

tert-Butyl[(4-hydroxybutyl)amino]acetate

Disolventes

diethyl ether

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe product mixture was washed successively with aqueous NaHCO3, water, and brine
2. 2
   ExtracciónThe organic extract
3. 3
   Secadowas dried over anhydrous sodium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated under vacuum
6. 6
   OtroThis intermediate was used in the following reaction without further purification

Procedimiento

To a cold (0° C.) solution of 4-hydroxybutylamine (9.1 g, 101.8 mmol) in diethyl ether (100 mL), a solution of tert-butyl bromoacetate (7.4 g, 49.3 mmol) in diethyl ether (25 mL) was added dropwise over a period of 2 hours. The reaction mixture was allowed to warm up slowly to room temperature and stirred at the temperature overnight. The product mixture was washed successively with aqueous NaHCO3, water, and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. This intermediate was used in the following reaction without further purification.

Fuente