Reacción #462176

Ecuación de reacción

compound

N-[3,5-Bis(trifluoromethyl)benzyl]-2-chloro-N-methyl-4-phenyl-3-quinolinecarboxamide

MeNH2 methanol

→

title compound

N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylamino-4-phenyl-3-quinolinecarboxamide

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawith heating
2. 2
   Temperaturaunder reflux
3. 3
   OtroThe solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
5. 5
   LavadoThe solution was washed with water
6. 6
   Otrodried
7. 7
   Otroevaporated

Procedimiento

To a solution of the compound obtained in Example 269 (100 mg) in ethanol (4 ml) was added 40% MeNH2 -methanol (12 ml), and the mixture was stirred for 4 hours with heating under reflux. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried and evaporated to yield the title compound as colorless crystals (65 mg).

Fuente