Reacción #46174

Ecuación de reacción

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester

p-toluene sulfonic acid

→

title compound

Rendimiento 75.3%

3-phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate methyl ester

Rendimiento 75.3%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was reacted for 1 hour at 70° C.
2. 2
   Lavadowashed with brine
3. 3
   ExtracciónThe organic layer was extracted with ethyl acetate
4. 4
   Secadodried over anhydrous sulfonate sulfate
5. 5
   Concentraciónconcentrated
6. 6
   Otrothe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9)

Procedimiento

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester (1.65 g, 4.0 mmol) prepared in (Step 5) of Example 1 was dissolved in methanol (160 ml) and p-toluene sulfonic acid (228 mg, 1.2 mmol) was added thereto. The mixture was reacted for 1 hour at 70° C., and then washed with brine. The organic layer was extracted with ethyl acetate, dried over anhydrous sulfonate sulfate, concentrated, and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:9) to obtain the title compound (yield 75.3%) as a red solid.

Fuente