Reacción #46168

Ecuación de reacción

Hydroxy amine

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

hydrochloric acid

pyridine

→

1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile

Rendimiento 45.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe organic layer extracted with ethyl acetate
2. 2
   Lavadowas washed with distilled water
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   Concentraciónconcentrated
5. 5
   Otrothe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2)

Procedimiento

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (200 mg, 0.547 mmol) was dissolved in ethanol. Hydroxy amine.hydrochloric acid (114 mg, 1.64 mmol) and pyridine (173 mg, 2.18 mmol) were added thereto and the mixture was stirred for 4 hours at 70° C. The organic layer extracted with ethyl acetate was washed with distilled water, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2) to obtain trails 1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile (95 mg, yield 45%) as a red solid,

Fuente