Reacción #46158

Ecuación de reacción

5-Chloromethyl benzo[1,3]dioxol

potassium carbonate

sodium iodide

ethyl benzoylacetate

→

2-benzo[1,3]dioxol-5-ylmethyl-3-oxo-3-phenylpropionate ethyl ester

Rendimiento 76.5%

Disolventes

Dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe reaction mixture was extracted with ammonium chloride and ether
2. 2
   Otrothe organic layer was separated
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   Concentraciónconcentrated
5. 5
   Otrothe resulting residue was purified by column chromatography

Procedimiento

5-Chloromethyl benzo[1,3]dioxol (11.2 g, 65.7 mmol) was dissolved in Dimethylformamide. Then, potassium carbonate (18.2 g, 131.4 mmol), sodium iodide (10.8 g, 72.27 mmol) and ethyl benzoylacetate (12.5 ml, 72.27 mmol) were added thereto and stirred for 5 hours at room temperature. The reaction mixture was extracted with ammonium chloride and ether, the organic layer was separated, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 2-benzo[1,3]dioxol-5-ylmethyl-3-oxo-3-phenylpropionate ethyl ester (16.4 g, 76%).

Fuente